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DETERMINING THE RISK OF CARDIOVASCULAR DISEASE IN PATIENTS DIAGNOSED WITH SCHIZOPHRENIA AND BIPOLAR AFFECTIVE

Filiz İzci1, Batuhan Ayık1, Servet İzci2

  • 1Sağlık Bilimleri University, Faculty of Medicine, Department of Psychiatry, Erenkoy mental and nervous diseases training and research hospital, Istanbul, Turkiye.

Psychiatria Danubina
|July 22, 2023
PubMed

Insights

Patients with Schizophrenia (SCZ) and Bipolar Affective Disorder (BAD) face increased cardiac arrhythmia risk. Factors like diabetes, antipsychotic use, and Framingham Heart Risk Score contribute to this risk, necessitating careful cardiac monitoring.

Area of Science:

  • Cardiology
  • Psychiatry
  • Pharmacology

Background:

  • Schizophrenia (SCZ) and Bipolar Affective Disorder (BAD) are associated with increased cardiovascular risks.
  • Assessing cardiac arrhythmia risk in these patient populations is crucial for improving outcomes.

Purpose of the Study:

  • To investigate cardiac arrhythmia risk in SCZ and BAD patients using electrocardiogram (ECG) parameters.
  • To correlate ECG markers of ventricular repolarization with clinical factors and cardiac risk scores.

Main Methods:

  • A total of 393 patients (140 BAD, 253 SCZ) were included.
  • ECG parameters (QT, QTc, TPe, TPe/QTc ratios) were measured.
  • Clinical data including Framingham Heart Risk Scoring (FHRS), comorbidities, and medication use were collected.

Main Results:

  • FHRS was higher in smokers, females, and patients with diabetes mellitus (DM).
  • Ventricular repolarization markers (QTc, TPe) correlated positively with FHRS, antipsychotic use, age, disease duration, and hospitalizations.
  • Elevated QTc rates were observed in females, DM patients, and those on multiple medications.

Conclusions:

  • Diabetes, polypharmacy, high FHRS, antipsychotic load, and disease chronicity increase cardiac arrhythmia risk in SCZ and BAD patients.
  • Proactive cardiac risk assessment and management are essential for patients with chronic psychiatric conditions.
  • Reducing cardiac mortality and morbidity requires tailored treatment and monitoring strategies for these vulnerable patients.
Abstract

Keywords:
Bipolar Affective DisorderElectrocardiogramFramingham Heart Risk ScoreSchizophrenia

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