Related Experiment Video

Updated: Jul 22, 2025

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

6.8K

Recent advances in novel miRNA mediated approaches for targeting breast cancer

Seyedeh Melika Ahmadi1, Shervin Amirkhanloo1, Rezvan Yazdian-Robati2

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Journal of Drug Targeting
|July 22, 2023
PubMed

Insights

MicroRNAs (miRNAs) are key players in breast cancer development and progression. This study explores miRNA biogenesis, function, and therapeutic potential for improved breast cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer (BC) is a leading global cancer in women.
  • Treatment challenges include drug resistance, tumor heterogeneity, and metastasis.
  • Breast cancer stem cells contribute to treatment failure and recurrence.

Purpose of the Study:

  • To review the biogenesis and function of microRNAs (miRNAs) in breast cancer.
  • To explore the potential of miRNAs as biomarkers for breast cancer.
  • To discuss miRNA-based therapeutic strategies for breast cancer treatment.

Main Methods:

  • Literature review of miRNA biogenesis and function in breast cancer.
  • Analysis of studies reporting aberrant miRNA expression in breast cancer pathogenesis.
  • Review of current and emerging miRNA-targeted therapy approaches.

Main Results:

  • Aberrant miRNA expression is linked to breast cancer development and progression.
  • Specific miRNAs show potential as diagnostic and prognostic biomarkers.
  • miRNAs can be targeted for therapeutic intervention in breast cancer cells.

Conclusions:

  • Understanding miRNA roles is crucial for advancing breast cancer therapies.
  • miRNA-based approaches offer promising avenues for more effective breast cancer treatment.
  • Targeting miRNAs could overcome challenges associated with conventional breast cancer therapies.
Keywords:
biomarkersbreast cancercancerdrug deliverymiRNApolymer

More Related Videos

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.7K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.4K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K