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New bisabolane-type sesquiterpenoid from Aspergillus sydowii BTBU20213012
Xinjun Zhang1, Yifei Dong2, Xinyu Liu2
1Institute of Tibet Plateau Ecology, Key Laboratory of Forest Ecology in Tibet Plateau, Ministry of Education of China, Tibet Agriculture & Animal Husbandry University, Nyingchi, Tibet, P. R. China.
Abstract:
A new bisabolane-type sesquiterpenoid, named (+)-8-dehydroxylaustrosene (1), along with ten known compounds, penicibisabolanes E (2) and G (3), (+)-austrosene (4), (S)-(+)-11-dehydrosydonic acid (5), sydonic acid (6), (7S,11S)-(+)-12-hydroxysydonic acid (7), (-)-(R)-hydroxysydonic acid (8), pseudaboydin A (9), (-)-(7 R,10R)-iso-10-hydroxysydowic acid (10), lumichrome (11), were identified from the fungus Aspergillus sydowii BTBU20213012 isolated from a marine sediment sample from the Western Pacific. The structures of the compounds were identified by HRESIMS and NMR data analysis. Compound 11 showed weak antimicrobial activity against Staphylococcus aureus with MIC value of 200 μg/mL.
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