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Cuproptosis in lung cancer: mechanisms and therapeutic potential
Qixuan Li1,2,3, Tianyi Wang1,2,3, Youlang Zhou4
1Medical School of Nantong University, Nantong University, Nantong, 226001, China.
Abstract:
Cuproptosis, a recently identified form of cell death that differs from other forms, is induced by the disruption of the binding of copper to mitochondrial respiratory acylation components. Inducing cell cuproptosis and targeting cell copper death pathways are considered potential directions for treating tumor diseases. We have provided a detailed introduction to the metabolic process of copper. In addition, this study attempts to clarify and summarize the relationships between cuproptosis and therapeutic targets and signaling pathways of lung cancer. This review aims to summarize the theoretical achievements for translating the results of lung cancer and cuproptosis experiments into clinical treatment.
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