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Updated: Jul 22, 2025

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

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Published on: December 22, 2020

Advanced software for MRgFUS treatment planning.

Antria Filippou¹, Andreas Georgiou¹, Anastasia Nikolaou¹

¹Cyprus University of Technology, Department of Electrical Engineering, Computer Engineering, and Informatics, 30 Archbishop Kyprianou Str., Limassol 3036, Cyprus.

Computer Methods and Programs in Biomedicine

|July 22, 2023

Summary

A new software platform simplifies 3D Focused Ultrasound (FUS) treatment planning using MRI. This system enables accurate planning, real-time monitoring, and robotic control for MR-guided FUS procedures.

Keywords:

HIFU MRgFUS Software Treatment planning

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Area of Science:

Medical Imaging
Ultrasound Technology
Robotics

Background:

Magnetic Resonance Imaging (MRI) is crucial for visualizing soft tissues.
Focused Ultrasound (FUS) offers non-invasive therapeutic options.
Integrated planning and guidance systems are needed for advanced FUS treatments.

Purpose of the Study:

To present a user-friendly software platform for 3D Focused Ultrasound (FUS) treatment planning.
To enable seamless integration with MRI and robotic systems for MR-guided FUS (MRgFUS).

Main Methods:

Direct retrieval and loading of MRI images within the software.
Utilizing design tools for defining treatment areas and sonication parameters.
Controlling robotic systems for precise FUS delivery and real-time monitoring via MRI and thermometry.

Main Results:

Successful integration of the software with MRI and robotic systems.
Demonstrated accurate treatment planning and real-time monitoring capabilities.
Exceptional agreement between planned treatment areas and actual lesions in phantom studies.

Conclusions:

The developed software facilitates accurate MR-guided FUS treatment planning and execution.
The platform offers a user-friendly interface for enhanced clinical workflow.
Future enhancements may include dynamic modulation of ultrasonic parameters during treatment.