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Usefulness of HANBAH Score in Japanese Patients With Acute Heart Failure

Tomohiro Kaneko1, Nobuyuki Kagiyama2, Yutaka Nakamura1

  • 1Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

The American Journal of Cardiology
|July 23, 2023
PubMed

Insights

The HANBAH score effectively predicts outcomes in acute heart failure patients. This simple score, based on hemoglobin, age, sodium, BUN, atrial fibrillation, and HDL, showed strong risk stratification capabilities in an external validation cohort.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Risk Stratification

Background:

  • Acute heart failure (AHF) poses a significant clinical challenge, necessitating accurate risk stratification tools.
  • Existing risk scores vary in complexity and performance, highlighting the need for simple yet effective predictors of AHF outcomes.

Purpose of the Study:

  • To validate the novel HANBAH (Hemoglobin, Age, Sodium, Blood Urea Nitrogen, Atrial Fibrillation, High-density Lipoprotein) risk score in an independent cohort of patients hospitalized for acute heart failure.
  • To compare the performance of the HANBAH score against other established risk scores, including AHEAD, AHEAD-U, and ACUTE HF.

Main Methods:

  • A retrospective analysis of 744 patients hospitalized for acute heart failure between 2015 and 2019.
  • The HANBAH score was calculated based on predefined criteria for hemoglobin, age, serum sodium, blood urea nitrogen, atrial fibrillation, and high-density lipoprotein levels.
  • Statistical analyses included Cox proportional hazards models and receiver operating characteristic (ROC) curve analysis to assess the association with all-cause death, death/rehospitalization, and in-hospital death.

Main Results:

  • The HANBAH score was significantly associated with all-cause death (aHR 1.38), composite of death and heart failure rehospitalization (aHR 1.27), and in-hospital death (aHR 1.66).
  • The HANBAH score demonstrated superior performance compared to AHEAD and AHEAD-U scores and comparable performance to the ACUTE HF score in predicting adverse outcomes.
  • The score showed powerful risk stratification capabilities in this external Japanese cohort.

Conclusions:

  • The HANBAH score is a simple yet powerful tool for risk stratification in patients with acute heart failure.
  • Its validated performance in an external cohort supports its utility in clinical practice for predicting adverse events.
  • The HANBAH score offers a valuable alternative to more complex risk assessment tools due to its simplicity and effectiveness.

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