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Gentamicin removal during intermittent peritoneal dialysis

S Indraprasit, V Ukaravichien, C Pummangura

    Nephron
    |January 1, 1986
    PubMed

    Insights

    Intermittent peritoneal dialysis effectively removes gentamicin in uremic patients. Dialysate drug concentration and protein loss significantly influence gentamicin clearance during this treatment.

    Area of Science:

    • Nephrology
    • Pharmacokinetics
    • Dialysis

    Background:

    • Gentamicin is an antibiotic commonly used for infections.
    • Uremic patients often require dialysis, necessitating an understanding of drug removal during this process.

    Purpose of the Study:

    • To investigate the removal of gentamicin during intermittent peritoneal dialysis (IPD).
    • To determine factors influencing gentamicin clearance and its pharmacokinetics in uremic patients undergoing IPD.

    Main Methods:

    • Studied 13 uremic patients receiving gentamicin intravenously.
    • Measured serum and dialysate gentamicin levels during IPD.
    • Assessed peritoneal gentamicin clearance and its correlation with protein loss and other solutes.

    Main Results:

    • Significant gentamicin removal was observed during IPD.
    • Peritoneal gentamicin clearance correlated with protein loss and was enhanced by 4% glucose dialysate and increased ultrafiltration.
    • Gentamicin dialysate levels did not correlate with serum concentrations.

    Conclusions:

    • Intermittent peritoneal dialysis is an effective method for gentamicin removal in uremic patients.
    • Factors such as protein loss and dialysate composition influence gentamicin clearance during IPD.

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