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Development and Validation of Nomogram Based on the Systemic-Immune Inflammation Response Index for Predicting

Faysal Şaylık1, Tufan Çınar2, Remzi Sarıkaya1

  • 1Department of Cardiology, Van Education and Research Hospital, Van, Turkey.

Angiology
|July 24, 2023
PubMed

Insights

The novel Systemic Immune Inflammation Response Index (SIIRI) effectively predicts contrast-induced nephropathy (CIN) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). SIIRI offers superior predictive ability compared to the Systemic Immune Inflammation Index (SII).

Area of Science:

  • Cardiology
  • Nephrology
  • Inflammation markers

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI).
  • The Systemic Immune Inflammation Response Index (SIIRI), a novel inflammatory marker, has shown associations with coronary artery disease severity.

Purpose of the Study:

  • To evaluate the predictive capability of SIIRI for CIN development in STEMI patients post-pPCI.
  • To develop and validate a nomogram utilizing SIIRI for CIN risk stratification.

Main Methods:

  • A cohort of 2289 STEMI patients undergoing pPCI was analyzed.
  • CIN was defined as a >0.5 mg/dL or 25% increase in serum creatinine within 72 hours post-pPCI.
  • A nomogram was constructed and validated for predicting CIN risk based on SIIRI and other clinical factors.

Main Results:

  • Patients who developed CIN (219) exhibited significantly higher SIIRI levels compared to those who did not (2070).
  • SIIRI was identified as an independent predictor of CIN and demonstrated superior discrimination compared to the Systemic Immune Inflammation Index (SII).
  • The SIIRI-based nomogram showed good calibration and discrimination for predicting CIN, outperforming a baseline model when SIIRI was added.

Conclusions:

  • SIIRI is a valuable and independent predictor of CIN in STEMI patients undergoing pPCI.
  • The developed SIIRI-based nomogram provides a useful tool for risk stratification of CIN.
  • SIIRI offers enhanced predictive performance over SII for CIN detection in this patient population.

Keywords:
ST-segment elevation myocardial infarctioncontrast-induced nephropathycoronary angiographysystemic immune inflammation response index

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