Related Experiment Video
Updated: Jul 22, 2025
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Bibliometric and visualization analysis of matrix metalloproteinases in ischemic stroke from 1992 to 2022
Background:
Matrix metalloproteinases (MMPs) are important players in the complex pathophysiology of ischemic stroke (IS). Recent studies have shown that tremendous progress has been made in the research of MMPs in IS. However, a comprehensive bibliometric analysis is lacking in this research field. This study aimed to introduce the research status as well as hotspots and explore the field of MMPs in IS from a bibliometric perspective.
Methods:
This study collected 1,441 records related to MMPs in IS from 1979 to 2022 in the web of science core collection (WoSCC) database, among them the first paper was published in 1992. CiteSpace, VOSviewer, and R package "bibliometrix" software were used to analyze the publication type, author, institution, country, keywords, and other relevant data in detail, and made descriptive statistics to provide new ideas for future clinical and scientific research.
Results:
The change in the number of publications related to MMPs in IS can be divided into three stages: the first stage was from 1992 to 2012, when the number of publications increased steadily; the second stage was from 2013 to 2017, when the number of publications was relatively stable; the third stage was from 2018 to 2022, when the number of publications began to decline. The United States and China, contributing more than 64% of publications, were the main drivers for research in this field. Universities in the United States were the most active institutions and contributed the most publications. STROKE is the most popular journal in this field with the largest publications as well as the most co-cited journal. Rosenberg GA was the most prolific writer and has the most citations. "Clinical," "Medical," "Neurology," "Immunology" and "Biochemistry molecular biology" were the main research areas of MMPs in IS. "Molecular regulation," "Metalloproteinase-9 concentration," "Clinical translation" and "Cerebral ischemia-reperfusion" are the primary keywords clusters in this field.
Conclusion:
This is the first bibliometric study that comprehensively mapped out the knowledge structure and development trends in the research field of MMPs in IS in recent 30 years, which will provide a reference for scholars studying this field.
Insights
This bibliometric analysis reveals key trends in matrix metalloproteinase (MMP) research for ischemic stroke (IS). The United States and China lead publications, with "molecular regulation" and "clinical translation" emerging as key research areas.
Area of Science:
- Neuroscience
- Biochemistry
- Immunology
Background:
- Matrix metalloproteinases (MMPs) play a critical role in the pathophysiology of ischemic stroke (IS).
- Research on MMPs in IS has advanced significantly, but a comprehensive bibliometric analysis was lacking.
- This study provides a bibliometric perspective on the research status and hotspots of MMPs in IS.
Purpose of the Study:
- To conduct a bibliometric analysis of research on matrix metalloproteinases (MMPs) in ischemic stroke (IS).
- To identify research status, hotspots, and development trends in the field of MMPs and IS over the past 30 years.
- To provide insights for future clinical and scientific research in this area.
Main Methods:
- Collected 1,441 records on MMPs in IS from the Web of Science Core Collection (1979-2022).
- Utilized CiteSpace, VOSviewer, and R package 'bibliometrix' for bibliometric analysis.
- Analyzed publication types, authors, institutions, countries, keywords, and research areas.
Main Results:
- Publication trends show steady growth (1992-2012), stability (2013-2017), and a decline (2018-2022).
- The United States and China are the leading contributors, accounting for over 64% of publications.
- Key research areas include 'Molecular regulation,' 'Metalloproteinase-9 concentration,' 'Clinical translation,' and 'Cerebral ischemia-reperfusion'.
Conclusions:
- This is the first bibliometric study comprehensively mapping the knowledge structure and development trends of MMPs in IS research.
- The findings offer a valuable reference for researchers in the field of MMPs and ischemic stroke.
- Highlights key research areas and geographical contributions, guiding future research directions.
