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Related Experiment Video

Updated: Jul 22, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

Computerized working memory training for hypertensive individuals with executive function impairment: a randomized

Regina Silva Paradela¹, Brenno Cabella², Mariana Penteado Nucci³

¹Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Frontiers in Neuroscience

|July 24, 2023

Summary

Cogmed working memory (WM) training did not improve cognitive function in hypertensive individuals. However, it did lead to more efficient brain activity in key areas, suggesting potential neural benefits.

Keywords:

cognitive dysfunction executive function hypertension magnetic resonance imaging rehabilitation

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Last Updated: Jul 22, 2025

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Neuroscience
Cognitive Psychology
Clinical Medicine

Background:

Hypertension is linked to impaired working memory (WM).
The efficacy of Cogmed WM training in hypertensive individuals with executive function (EF) deficits remains uninvestigated.
This study addresses the knowledge gap regarding Cogmed's impact on this population.

Purpose of the Study:

To assess the effects of Cogmed WM training on the cognitive performance of hypertensive patients with EF impairment.
To explore changes in neuronal activity using functional magnetic resonance imaging (fMRI) following Cogmed intervention.

Main Methods:

Forty hypertensive patients (aged 40-70) with EF impairment were randomized to 10 weeks of Cogmed or control training.
Cognitive outcomes, including WM, verbal memory, and executive function, were primary and secondary endpoints.
fMRI was used to measure brain activity during low and high WM load tasks.

Main Results:

Cogmed training did not significantly improve WM or other cognitive outcomes compared to the control group.
fMRI revealed decreased activation in the right superior parietal lobe (WM-low load) and left inferior frontal lobe (WM-high load) in the Cogmed group.
These activation changes suggest more efficient neural processing in WM-related networks post-training.

Conclusions:

Cogmed WM training did not enhance cognitive performance in hypertensive individuals with EF impairment.
Despite no cognitive improvements, observed reductions in frontoparietal brain activity indicate potentially more efficient neuronal function after training.