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Acute coronary syndrome in antineutrophil cytoplasmic antibody-associated vasculitis: a Korean single-centre cohort

Jin Seok Kim1, Yong-Beom Park1,2, Sang-Won Lee1,2

  • 1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Journal of Rheumatic Diseases
|July 24, 2023
PubMed

Insights

The incidence of acute coronary syndrome (ACS) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) was 2.7%. Non-ST-segment elevation myocardial infarction (NSTEMI) was the most frequent ACS type, with male sex being a predictor.

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of systemic autoimmune diseases.
  • Patients with AAV have an increased risk of cardiovascular events.
  • Understanding the cardiovascular risk profile in AAV is crucial for patient management.

Purpose of the Study:

  • To determine the incidence and patterns of acute coronary syndrome (ACS) in patients with AAV.
  • To identify predictors of ACS in a cohort of Korean patients diagnosed with AAV.

Main Methods:

  • A single-centre cohort study included 262 patients diagnosed with AAV.
  • Acute coronary syndrome (ACS) was defined as ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) occurring during or after AAV diagnosis.
  • Clinical variables were analyzed to identify predictors of ACS.

Main Results:

  • The incidence of ACS in patients with AAV was 2.7% (7 patients).
  • Non-ST-segment elevation myocardial infarction (NSTEMI) was the most common type of ACS.
  • Male sex was identified as the only significant predictor of ACS in patients with AAV.

Conclusions:

  • The incidence of ACS in Korean patients with AAV is 2.7%.
  • NSTEMI is the predominant form of ACS in this population.
  • Male sex is a significant risk factor for ACS development in AAV patients.
Abstract

Keywords:
Acute coronary syndromeAntineutrophil cytoplasmic antibodyVasculitis

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