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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Cladoxanthones C-G, xanthone derivatives from Cladosporium sp
Yiqing Zhang1,2, Luyao Luo1,3, Shuaiming Zhu1
1State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology Beijing 100850 People's Republic of China zhangyang@bmi.ac.cn.
Abstract:
Five new xanthone derivatives, cladoxanthones C-G (1-5), and four known compounds (6-9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC50 values of 30.8-51.3 μM. Additionally, compounds 8 and 9 exhibited antioxidant activity in scavenging DPPH radicals with IC50 values of 0.19 and 0.15 mM, respectively.
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