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PHF5A as a new OncoTarget and therapeutic prospects
Xiaojiang Li1, Dalong Liu1, Yun Wang2
1Department of Orthopedics, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130000, China.
Heliyon
|July 24, 2023
Summary
PHF5A, a protein essential for splicing, also drives cancer progression by affecting cell growth and differentiation. Targeting PHF5A offers a potential strategy for cancer treatment.
Area of Science:
- Molecular Biology
- Cancer Research
- Cell Biology
Background:
- PHF5A (PHD-finger domain protein 5A) is a conserved nuclear protein involved in pre-mRNA splicing as part of the SF3B complex.
- It plays roles in cell cycle, differentiation, DNA repair, stem cell maintenance, and chromatin regulation.
- PHF5A's involvement in cancer pathogenesis, including lung, endometrial, breast, and colorectal cancers, requires further investigation.
Purpose of the Study:
- To review the structural and functional characteristics of PHF5A.
- To elucidate the role of PHF5A in cancer pathogenesis and its potential as a therapeutic target.
Main Methods:
- Literature review of PHF5A's functions.
- Analysis of PHF5A's involvement in splicing and non-splicing pathways.
- Examination of PHF5A's role in various cancer types and cancer stem cell regulation.
Main Results:
- PHF5A is crucial for pre-mRNA splicing and regulates alternative splicing.
- It acts as an oncogenic protein, promoting tumorigenesis through signaling pathways and dysregulated gene splicing.
- PHF5A influences cancer stem cell growth and is implicated in multiple cancer types.
Conclusions:
- PHF5A has significant spliceosome and non-spliceosome functions.
- Its oncogenic activity and role in cancer stem cells highlight its importance in cancer progression.
- PHF5A represents a promising therapeutic target for cancer management.
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