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Effects of renal denervation on cardiac function after percutaneous coronary intervention in patients with acute

Jun-Qing Gao1,2, You-Long Xu1,2, Jian Ye1,2

  • 1Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Heliyon
|July 24, 2023
PubMed

Insights

Renal artery denervation (RDN) improved cardiac function and exercise tolerance in patients with acute myocardial infarction after percutaneous coronary intervention (AMI-PCI). This suggests RDN may help restore the sympathetic-vagal balance in these patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Nephrology

Background:

  • Acute myocardial infarction (AMI) post percutaneous coronary intervention (PCI) can lead to impaired cardiac function.
  • The role of renal sympathetic nerve activity in post-AMI cardiac dysfunction is increasingly recognized.

Purpose of the Study:

  • To evaluate the impact of renal artery denervation (RDN) on cardiac function in patients with AMI following PCI.
  • To assess the effects of RDN on exercise capacity and heart rate variability (HRV) in this patient population.

Main Methods:

  • A prospective, randomized controlled study involving 108 AMI-PCI patients.
  • Patients were randomized to receive either RDN plus standard therapy or standard therapy alone.
  • Cardiac function, exercise tolerance (CPET), and HRV were assessed at baseline and 6 months post-intervention.

Main Results:

  • RDN significantly improved left ventricular ejection fraction compared to the control group.
  • Patients undergoing RDN demonstrated enhanced exercise capacity, indicated by higher VO2Max and metabolic equivalents.
  • RDN led to significant improvements in HRV parameters, suggesting a restored autonomic balance.

Conclusions:

  • Renal artery denervation is associated with improved cardiac function and exercise tolerance in AMI-PCI patients.
  • RDN may exert its beneficial effects by modulating sympathetic nervous system activity and restoring autonomic balance.
Abstract

Keywords:
Acute myocardial infarctionArrhythmiaCardiac functionRenal denervationSympathetic nervous system

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