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Ulvan/Silver nanoparticle hydrogel films for burn wound dressing
Evi Sulastri1,2, Ronny Lesmana3, Muhammad Sulaiman Zubair2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Heliyon
|July 24, 2023
Summary
A novel ulvan-silver nanoparticle hydrogel film dressing effectively treats second-degree burns. This advanced wound dressing accelerates healing by reducing inflammation and improving tissue regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Ulvan, a green algae polysaccharide, exhibits promising hydrogel film dressing properties.
- Silver nanoparticles (AgNP) enhance antibacterial activity and burn treatment potential.
Purpose of the Study:
- To develop and evaluate a novel hydrogel film wound dressing incorporating ulvan and silver nanoparticles.
- To assess the physicochemical properties, antimicrobial activity, and in vivo wound healing efficacy of the developed dressing.
Main Methods:
- Ulvan-silver nanoparticle hydrogel films (UHF-AgNP) were prepared using two silver nitrate concentrations (0.5 mM and 1 mM).
- Physicochemical characterization included particle size, zeta potential, FTIR, XRD, and SEM-EDX.
- In vitro antimicrobial activity and in vivo second-degree burn wound healing in Wistar rats were evaluated.
Main Results:
- The UHF-AgNP0.5 formulation exhibited superior antimicrobial activity compared to UHF-AgNP1 and the control (UHF film).
- In vivo studies demonstrated that UHF-AgNP0.5 significantly accelerated second-degree burn healing.
- Accelerated healing was attributed to regulated inflammation, enhanced re-epithelialization, and improved vascularization.
Conclusions:
- Ulvan-silver nanoparticle hydrogel films are effective in accelerating the healing of second-degree burns.
- These novel hydrogel films show significant potential as advanced wound dressings for burn injuries.
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