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Effect of Probiotic-Fortified Infant Formula on Infant Gut Health and Microbiota Modulation
Ju Young Eor1, Chul Sang Lee1,2, Sung Ho Moon1
1College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
Food Science of Animal Resources
|July 24, 2023
Summary
Probiotic infant formula improved gut health in infants, increasing beneficial bacteria and mimicking breast milk's positive effects. This formula enhanced stool consistency and maintained immune markers.
Area of Science:
- Neonatal nutrition and gut health
- Microbiome research
- Immunology
Background:
- Breast milk is optimal for infant nutrition, supporting gut function, immunity, and microbiota.
- Traditional infant formulas have limitations compared to breast milk.
- Probiotic-fortified formulas may offer enhanced benefits for the infant gut environment.
Purpose of the Study:
- To investigate the effects of probiotic-fortified infant formula on the gut environment, microbiota, and immune markers in infants.
- To compare probiotic formula with breast milk and placebo formula.
Main Methods:
- A one-month study involving 118 Korean infants divided into three groups: breast milk, probiotic formula, and placebo formula.
- Evaluation of stool consistency, defecation frequency, fecal acidity, and butyrate concentration.
- Analysis of fecal microbiota composition and secretory immunoglobulin A (sIgA) levels at weeks 0 and 4.
Main Results:
- Probiotic formula improved stool consistency and defecation frequency compared to placebo.
- The probiotic group maintained secretory immunoglobulin A (sIgA) levels, unlike the placebo group.
- Probiotic formula reduced stool acidity and increased butyrate concentration.
- Fecal microbiota analysis showed increased abundance of health-promoting bacteria in the probiotic group compared to placebo.
Conclusions:
- Supplementation with probiotic infant formula can optimize the infant gut environment.
- Probiotic formula positively influences microbial composition and metabolic activity, resembling breast milk.
- Probiotic infant formula offers a promising alternative for enhancing infant gut health.
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