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Precision oncology for children: A primer for paediatricians
Sarah Cohen-Gogo1, Avram E Denburg1,2, Anita Villani1,2
1Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Paediatrics & Child Health
|July 24, 2023
Summary
Precision oncology uses next-generation sequencing to personalize cancer treatment for young patients. This approach aims to improve survival rates for difficult-to-treat childhood cancers by identifying specific genetic targets.
Area of Science:
- Pediatric Oncology
- Genomics
- Molecular Diagnostics
Background:
- Childhood cancer remains a leading cause of death in North America.
- Improving survival rates for hard-to-cure pediatric cancers is a significant challenge.
- Precision oncology offers a personalized approach to cancer treatment.
Purpose of the Study:
- To provide an overview of precision pediatric oncology.
- To discuss its evolution, current applications, and future potential.
- To address challenges and limitations of its implementation.
Main Methods:
- Utilizes next-generation sequencing (NGS).
- Identifies genomic and transcriptomic alterations in tumors.
- Applies findings to diagnosis, prognosis, and treatment targeting.
Main Results:
- Precision oncology can clarify diagnoses and refine prognoses.
- It helps identify underlying genetic causes of cancer.
- Unique treatment targets can be identified for individual patients.
Conclusions:
- Precision oncology is evolving as a foundational approach in pediatric cancer care.
- Its implementation faces ethical and economic challenges.
- Further development is crucial for global application in Canada and worldwide.
Keywords:
CancerCancer predispositionMolecular tumour boardNext-generation sequencingPrecision medicineTargeted therapyMore Related Videos
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