Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

47.0K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
47.0K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.2K
Gene Families01:57

Gene Families

2.6K
2.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Genomics02:02

Genomics

36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K
Genetic Variation01:25

Genetic Variation

327
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
327

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicted bacterial uRBSs reveal translational coupling and ribosome-mediated RBS occlusion as gene-controlling mechanisms.

microLife·2026
Same author

Generative models for antimicrobial peptide design: auto-encoders and beyond.

BioData mining·2026
Same author

Shifting perspectives on the role of parents in the rehabilitation of children with higher body weight: insights from qualitative interviews with children, parents, and professionals.

Frontiers in pediatrics·2026
Same author

Towards FAIR and federated data ecosystems for interdisciplinary research.

PLoS computational biology·2026
Same author

From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum.

The Plant journal : for cell and molecular biology·2026
Same author

Pyrroline-5-carboxylate dehydrogenase is a key player in nitrogen metabolism in maturing seeds of Arabidopsis thaliana.

Journal of experimental botany·2026

Related Experiment Video

Updated: Jul 22, 2025

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.5K

The Viscum album Gene Space database.

Lucie Schröder1, Oliver Rupp2, Michael Senkler1

  • 1Plant Proteomics, Institute of Plant Genetics, Leibniz Universität Hannover, Hannover, Germany.

Frontiers in Plant Science
|July 24, 2023
PubMed
Summary

European mistletoe

Keywords:
Complexome profilingIllumina sequencingPacBio sequencingcomplex Idatabase developmentmitochondriaoxidative phosphorylation (OXPHOS)supercomplex

More Related Videos

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.8K

Related Experiment Videos

Last Updated: Jul 22, 2025

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.5K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

1.8K

Area of Science:

  • Plant genomics
  • Transcriptomics
  • Proteomics

Background:

  • Viscum album (European mistletoe) possesses an exceptionally large genome.
  • Previous transcriptome projects provided initial insights into its gene space.
  • A comprehensive gene space database is crucial for understanding its unique biology.

Purpose of the Study:

  • To develop an improved and more complete gene space database for Viscum album.
  • To enhance the understanding of Viscum album's genetic and proteomic makeup.
  • To facilitate future research into the plant's extraordinary properties.

Main Methods:

  • Combined PacBio and Illumina sequencing for transcriptome analysis.
  • Development of the Viscum album Gene Space database II (VaGs II).
  • Bioinformatic filtering to remove non-target sequences (e.g., fungal).
  • BUSCO analysis for database completeness assessment.
  • Re-analysis of mitochondrial proteome data.

Main Results:

  • The VaGs II database contains 90,039 sequences with 93% completeness (BUSCO).
  • Significantly improved identification of proteins in the mitochondrial fraction, revealing new insights into oxidative phosphorylation.
  • Removal of contaminating fungal sequences enhanced data quality.

Conclusions:

  • The VaGs II database represents a significant advancement in Viscum album genomics.
  • This enhanced resource provides a more accurate view of the plant's gene space.
  • The improved proteomic data offers novel perspectives on Viscum album's metabolic pathways.