The brain fibroblast growth factor (FGF) is localized in neurons

The physiological role of fibroblast growth factor (FGF), like many other characterized growth factors, is poorly understood. Therefore, it would be useful to know in which cell type this growth factor is present. Using monoclonal and polyclonal antibodies against FGF, we have localized this molecule in rat brain. Interestingly, FGF is found exclusively in neuronal cells. Since FGF stimulates the proliferation and maturation of glial cells in vitro, its involvement in the interaction between neuronal and glial cells in vivo is likely. A role in the triggering of reactive gliosis can also be hypothesized.