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The impact of the apelinergic system in coronary collateral formation

İbrahim Özsoyler1, Haci Ali Uçak1, Tolga Onur Badak1

  • 1Department of Cardiovascular Surgery, Health Sciences University, Adana Şehir Training and Research Hospital, Adana, Türkiye.

Turk Gogus Kalp Damar Cerrahisi Dergisi
|July 24, 2023
PubMed

Insights

Serum elabela levels are linked to good coronary collateral circulation. Higher elabela indicates better collateral development, suggesting its potential as a therapeutic target for cardiovascular health.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) impacts millions globally.
  • Coronary collateral circulation (CCC) is a critical compensatory mechanism in CAD.
  • Understanding factors influencing CCC development is vital for patient outcomes.

Purpose of the Study:

  • To investigate the association between serum elabela levels and the development of CCC in patients with CAD.
  • To determine if elabela can serve as a predictive marker for CCC status.

Main Methods:

  • Cross-sectional study involving 150 participants (50 controls, 100 CAD patients) from January 2020 to December 2021.
  • Patients with CAD were stratified into groups with poor and good CCC based on Rentrop classification.
  • Serum elabela levels were measured and compared across all groups.

Main Results:

  • Serum elabela levels were significantly higher in patients with good CCC compared to those with poor CCC and controls (p<0.05).
  • Low serum elabela levels were associated with a 2.43-fold increased risk of developing poor CCC.

Conclusions:

  • The elabela protein is directly correlated with favorable collateral development in the coronary arteries.
  • Elabela shows potential as a therapeutic agent to promote collateral growth and improve outcomes in CAD patients.
Abstract

Keywords:
Apelinergic systemcoronary artery diseasecoronary collateralelabela

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