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Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
Systemic immune-inflammation index is associated with coronary heart disease: a cross-sectional study of NHANES
1West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China.
Insights
The systemic immune inflammation index (SII) may help predict coronary heart disease (CHD) risk. Higher SII levels were linked to lower odds of developing CHD, with gender influencing this association.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biomarker Research
Background:
- Systemic inflammation is implicated in coronary heart disease (CHD) development.
- The systemic immune inflammation index (SII) serves as a key biomarker for systemic inflammation.
- Understanding the relationship between SII and CHD is crucial for cardiovascular health.
Purpose of the Study:
- To investigate the correlation between the systemic immune inflammation index (SII) and coronary heart disease (CHD).
- To explore the potential of SII as a predictive biomarker for CHD.
- To analyze gender-specific associations between SII and CHD.
Main Methods:
- Multivariate logistic regression analysis was performed on a cohort of 15,905 participants.
- Smoothing curve fitting and segmented model comparison were employed to analyze the data.
- Adjustments were made for demographic factors including gender, age, and race.
Main Results:
- A negative association was observed between SII and CHD after adjusting for covariates (OR 0.66; 95% CI 0.48, 0.90).
- An inverse trend indicated that increasing SII levels correlated with decreased odds of CHD (p for trend = 0.0017).
- Smoothing curve analysis revealed a gender-specific relationship between SII and CHD.
Conclusions:
- Elevated SII levels may be associated with a reduced incidence of CHD, with variations observed based on gender.
- The systemic immune inflammation index (SII) presents a potentially cost-effective and accessible tool for CHD risk assessment.
- Further prospective research is warranted to establish causality and validate these findings in diverse populations.
Background:
Inflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker of systemic inflammation. Our study aimed to explore the correlation between SII and CHD.
Methods:
We conducted a multivariate logistic regression analysis, smoothing curve fitting, and segmented model comparison on 15,905 participants with a CHD prevalence of 3.31% and a mean age of 46.97 years.
Results:
Adjusting for gender, age, and race, we found a negative association between SII and CHD [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing SII was associated with decreasing odds of CHD (p for trend = 0.0017). After further adjustment, the association was strengthened, with a similar trend (p for trend = 0.0639). Smoothing curve fitting demonstrated a gender-specific association between SII and CHD.
Conclusions:
Our findings suggest that higher SII values may be associated with a higher incidence of CHD, which varies by gender. SII may be a cost-effective and convenient method to detect CHD. Further studies are needed to confirm the causality of these findings in a larger prospective cohort.
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