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Updated: Jul 22, 2025
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circular RNAs in hepatocellular carcinoma: biogenesis, function, and pathology
Guocheng Rao1,2, Xi Peng1,2, Yan Tian1
1Department of Endocrinology and Metabolism, Cancer Center West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in Genetics
|July 24, 2023
Summary
Circular RNAs (circRNAs) are key players in hepatocellular carcinoma (HCC) development. This review explores circRNAs
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally.
- Both genetic and environmental factors contribute to HCC pathogenesis via complex molecular mechanisms.
- Circular RNAs (circRNAs), a novel class of non-coding RNAs, are increasingly recognized for their roles in cancer initiation and progression.
Purpose of the Study:
- To review the current understanding of circRNAs in hepatocellular carcinoma (HCC).
- To emphasize the functions and mechanisms of circRNAs within the HCC tumor microenvironment.
- To summarize recent advancements in using circRNAs as biomarkers and therapeutic targets for HCC.
Main Methods:
- Literature review of recent studies on circRNAs in HCC.
- Analysis of circRNA functions, mechanisms, and roles in the HCC microenvironment.
- Synthesis of current research on circRNAs as diagnostic and therapeutic strategies.
Main Results:
- CircRNAs are implicated in the initiation and progression of HCC.
- Specific circRNAs influence the HCC microenvironment.
- Emerging evidence supports circRNAs as potential biomarkers and therapeutic targets for HCC.
Conclusions:
- CircRNAs represent a significant area of research in HCC.
- Understanding circRNA functions offers new avenues for HCC diagnosis and treatment.
- Further research into circRNAs is crucial for advancing HCC clinical management.
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