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Updated: Jul 22, 2025

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DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells

Yingying Wang1, Minli Wei1, Min Su1

  • 1Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China.

Iscience
|July 24, 2023
PubMed
Summary

DIRAS3 suppresses non-small-cell lung cancer (NSCLC) cell migration by targeting RAC1 for degradation. This discovery highlights the DIRAS3-RNF19B-RAC1 pathway as crucial for NSCLC progression and potential therapeutic targeting.

Keywords:
BiotechnologyCell biologyMolecular biology

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