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Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based
Aru Shikha Singh1, Lakshimi Borgohain2, Bhupindar Singh3
1Department of Psychiatry, Autonomous State Medical College, Firozabad, Uttar Pradesh, India.
Background:
The correlation between plasma C-reactive protein (CRP) and aggression in schizophrenia has recently become an area of interest. As an acute phase reactant, neuro-immuno-modulatory and neurohumoral functions of CRP might have a role in understanding causation of aggression in disease and this may have implications in therapeutic intervention.
Aims:
To assess aggression and plasma CRP in patients with schizophrenia and to compare aggression in patients with normal and elevated CRP.
Methods And Material:
A hospital-based cross-sectional study was carried out over a period of one year (2019-2020). Patients of schizophrenia as per International Classification of Diseases 10 were selected. Modified Overt Aggression Scale was applied, and plasma CRP levels were estimated in the selected patients.
Statistical Analysis:
Mean aggression scores were compared in patients with normal and elevated CRP. And aggression scores were correlated with plasma CRP levels.
Results:
Mean aggression score (22.93 ± 2.80) was significantly (P < .001) higher in patients with elevated CRP. There is a positive correlation (r = 0.855, P < .001) between aggression and plasma CRP.
Conclusion:
Patients with elevated CRP were more aggressive compared to the patients with normal CRP.
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