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Ocular complications of antineoplastic therapies

Abbas Bader1, Madeline Begemann2, Ammar Al-Obaidi2

  • 1University of Missouri Kansas City School of Medicine, 5000 Holmes St, Kansas City, MO 64110, USA.

Future Science OA
|July 24, 2023
PubMed

Insights

New cancer treatments are increasing ocular complications, affecting patient quality of life. Early detection and management through oncologist-ophthalmologist communication are crucial for addressing these vision issues.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pharmacology

Background:

  • Antineoplastic agents, including novel therapies, can cause significant ocular complications.
  • These side effects profoundly impact cancer patients' quality of life.
  • Ocular toxicities vary based on the specific antineoplastic agent's mechanism of action.

Purpose of the Study:

  • To review and synthesize current literature on ocular complications associated with antineoplastic agents.
  • To highlight the challenges in managing these vision-related side effects in cancer care.
  • To emphasize the importance of interdisciplinary collaboration for optimal patient outcomes.

Main Methods:

  • Comprehensive literature review of scientific journals.
  • Analysis of clinical studies and case reports.
  • Synthesis of data on ocular side effects from various antineoplastic therapies.

Main Results:

  • Novel cancer treatments like monoclonal antibodies, immunotherapies, and antibody-drug conjugates are associated with increased ocular complications.
  • The specific type and severity of ocular toxicity depend on the antineoplastic agent's mechanism.
  • Management of these complications presents significant challenges for cancer patient care.

Conclusions:

  • Ocular complications are a growing concern with modern antineoplastic therapies.
  • Effective management requires a thorough understanding of drug-specific toxicities.
  • Enhanced communication and collaboration between oncologists and ophthalmologists are essential for early detection and timely intervention.
Keywords:
antineoplastic agentscancerchemotherapyophthalmic side effects

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