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Visible-Light-Induced Control over Reversible Single-Chain Nanoparticle Folding.

Patrick H Maag1,2,3,4, Florian Feist4, Vinh X Truong5

  • 1School of Chemistry and Physics, Queensland University of Technology (QUT), 2 George Street, 4000, Brisbane, QLD, Australia.

Angewandte Chemie (International Ed. in English)
|July 24, 2023
PubMed
Summary

Researchers developed light-responsive single-chain nanoparticles (SCNPs) that unfold using visible light. This reversible process, monitored by SEC and DOSY, shows promise for biological applications.

Keywords:
BimanesReversible Polymer FoldingSingle-Chain NanoparticlesVisible Light Photochemistry

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Area of Science:

  • Polymer Chemistry
  • Nanotechnology
  • Photochemistry

Background:

  • Single-chain nanoparticles (SCNPs) offer tunable properties for various applications.
  • Controlling SCNP conformation is crucial for their function, especially in biological systems.

Purpose of the Study:

  • To introduce a novel class of SCNPs responsive to visible light.
  • To demonstrate reversible light-induced unfolding of these SCNPs.

Main Methods:

  • SCNPs synthesized via esterification of acrylic acid and polyethylene glycol with bimane moieties.
  • Photochemical unfolding triggered by visible light (λmax = 415 nm).
  • Characterization using Size Exclusion Chromatography (SEC) and Diffusion Ordered NMR Spectroscopy (DOSY) to monitor hydrodynamic radius (RH).

Main Results:

  • SCNPs demonstrated complete unfolding upon visible light exposure.
  • Folding and unfolding processes were reversible with high photo cleavage conversion.
  • Changes in hydrodynamic radius confirmed structural transitions.

Conclusions:

  • Developed a novel system for light-controlled SCNP conformation.
  • The reversible, light-triggered unfolding in aqueous media holds potential for biomedical applications.