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Updated: Jul 22, 2025

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

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PSMA Uptake in a Subdural Hematoma.

Tristan R Lawson¹, Sophia R O'Brien, Austin R Pantel

¹From the Hospital of the University of Pennsylvania, Philadelphia, PA.

Clinical Nuclear Medicine

|July 24, 2023

Summary

This summary is machine-generated.

Prostate cancer staging with PSMA PET/CT revealed a growing subdural hematoma. Despite intervention, the patient succumbed to rapid reaccumulation of blood products.

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Area of Science:

Oncology
Radiology
Neurology

Background:

Metastatic prostate cancer requires accurate restaging for treatment planning.
Prostate-specific membrane antigen (PSMA) PET/CT is an advanced imaging technique for cancer detection.

Observation:

An 81-year-old man with metastatic prostate cancer underwent PSMA PET/CT ( 18 F-piflufolastat) for restaging.
Imaging revealed a subdural hematoma with significant radiotracer uptake.
Comparison with prior CT scans showed substantial hematoma enlargement over two months.

Findings:

The subdural hematoma exhibited increased size and PSMA radiotracer activity.
The patient underwent emergent intervention, including subdural drain placement.
Rapid reaccumulation of subdural blood products occurred post-intervention.

Implications:

PSMA PET/CT may incidentally detect or monitor intracranial pathologies like subdural hematomas.
This case highlights the importance of comprehensive image review beyond the primary oncologic indication.
Further investigation is warranted to understand the mechanism of PSMA uptake in subdural hematomas.