Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders

Area of Science:

• Neuroscience
• Pharmacology
• Molecular Biology

Background:

• Anxiety and depression are prevalent neurological disorders affecting up to one-third of the population.
• Cyclic nucleotide monophosphates (cNMPs) like cAMP and cGMP are crucial in regulating neurotransmitter genes and neurological functions.
• Dysregulation of cNMP pathways (e.g., cAMP/cGMP, CREB, PKA) is implicated in the pathophysiology of these disorders.

Purpose of the Study:

• To review the molecular mechanisms by which plant and mushroom-derived bioactive compounds modulate cNMP pathways.
• To explore the potential of these natural compounds in treating anxiety and depression disorders.

Main Methods:

• Literature review focusing on studies investigating bioactive compounds from plants and mushrooms.
• Analysis of research on the modulation of cNMP pathways (cAMP, cGMP, CREB, PKA) by these compounds.
• Examination of the link between these modulations and the physiopathology of anxiety and depression.

Main Results:

• Plant and mushroom-derived compounds possess bioactive properties that can influence cNMP metabolism.
• These compounds activate key signaling pathways, offering potential pharmacological outcomes.
• Evidence suggests these natural compounds can modulate crucial cNMP pathways involved in neurological functions.

Conclusions:

• Understanding the molecular mechanisms of plant and mushroom compounds in modulating cNMP pathways is vital.
• These natural agents show promise for supporting current treatments and developing novel therapeutic strategies for anxiety and depression.
• Further research can lead to improved prevention and treatment outcomes for these widespread neurological disorders.