Related Experiment Video

Updated: Jul 22, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

458

The CRISPR/Cas System in Human Cancer

Martín Hérnan Bonamino1, Eduardo Mannarino Correia2

  • 1Instituto Nacional do Câncer, Coordenação de Pesquisa, Rio de Janeiro, RJ, Brazil. mbonamino@inca.gov.br.

Advances in Experimental Medicine and Biology
|July 24, 2023
PubMed

Insights

CRISPR gene editing technology simplifies genome manipulation in oncology research. This review highlights its applications in biological screenings, model generation, and developing novel cancer treatments.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • CRISPR technology offers a revolutionary approach to genetic editing.
  • Its application has significantly impacted cancer research, from basic science to clinical applications.

Purpose of the Study:

  • To review the diverse applications of CRISPR technology in oncology.
  • To explore its role in advancing cancer knowledge and treatment strategies.

Main Methods:

  • In vitro and in vivo biological screenings using CRISPR.
  • Generation of cellular and animal models for cancer research.
  • Development of novel CRISPR-derived tools for cancer studies.

Main Results:

  • CRISPR facilitates simple, fast, and cost-effective genome manipulation.
  • The technology enhances the understanding of cancer biology.
  • It provides new avenues for developing improved cancer therapies.

Conclusions:

  • CRISPR gene editing is a transformative tool in oncology research.
  • It accelerates discovery and offers promising solutions for cancer treatment.
  • Continued innovation in CRISPR technology will further advance cancer care.

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