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Dupilumab-Associated Sweet Syndrome.

Edward Fernandez¹, Wells Chandler¹, Paul R Long¹

¹Drs. Fernandez and Fadugba are from the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Drs. Chandler, Long, and Palmer are from Geisinger Medical Center, Danville, Pennsylvania. Dr. Chandler is from the Department of Laboratory Medicine, and Drs. Long and Palmer are from the Department of Dermatology.

|July 24, 2023

Summary

Sweet syndrome (SS), a skin condition, can rarely be triggered by dupilumab, a medication for asthma. Prompt recognition and treatment are crucial for managing this adverse reaction.

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Area of Science:

Dermatology
Immunology
Pharmacology

Background:

Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, presents with sudden onset of skin lesions.
SS has various subtypes, including idiopathic and drug-induced forms.

Observation:

A rare case of SS is reported, specifically linked to dupilumab therapy.
Dupilumab is a monoclonal antibody used for severe eosinophilic asthma and other conditions.

Findings:

This case highlights dupilumab as a potential, albeit rare, causative agent for Sweet syndrome.
The histopathologic findings in SS are distinct and aid in diagnosis.

Implications:

Clinicians must consider dupilumab-induced SS as a potential adverse drug reaction.
Early identification and management of this condition are essential for patient outcomes.