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Quantifying Ligand Binding to the Surface of Metal-Organic Frameworks
Austin Wang1, Kyle Barcus1, Seth M Cohen1
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States.
Journal of the American Chemical Society
|July 24, 2023
Summary
Understanding molecule binding to metal-organic frameworks (MOFs) surfaces is crucial. This study quantifies ligand binding to MOF exteriors using dye displacement, revealing key insights for MOF modification.
Area of Science:
- Materials Science
- Surface Chemistry
- Nanotechnology
Background:
- The surface interactions of metal-organic frameworks (MOFs) with external molecules remain poorly understood.
- Developing methods to quantify these interactions is essential for MOF applications.
- MOFs offer tunable properties for catalysis, separation, and sensing.
Purpose of the Study:
- To investigate the surface chemistry of three distinct MOFs: UiO-66, MIL-88B-NH2, and ZIF-8.
- To quantitatively evaluate the binding affinities of various ligands to MOF surfaces.
- To provide insights into the modulation and modification of MOF properties.
Main Methods:
- Dye-displacement experiments were employed to probe MOF surface chemistry.
- MOF surfaces were functionalized with ligand-appended BODIPY dyes.
- Ultraviolet-visible spectroscopy was utilized to measure dye displacement and apparent binding constants.
Main Results:
- Apparent binding constants for different ligands interacting with MOF surfaces were successfully measured.
- Ligand affinity was found to be dependent on the specific metal-ligand composition of the MOF.
- The study established a quantitative method for assessing MOF surface interactions.
Conclusions:
- This work offers a quantitative assessment of ligand binding to MOF surfaces.
- The findings provide valuable insights for the rational design and manipulation of MOFs.
- Understanding surface binding is critical for optimizing MOF performance in various applications.
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