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Updated: Jul 22, 2025

Bridging the Bio-Electronic Interface with Biofabrication
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Organic functional substance engineered living materials for biomedical applications.

Tongtong Wang1, Min Wu2, Lei Cao1

  • 1Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, 350207, China; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore.

Biomaterials
|July 24, 2023
PubMed
Summary

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Organic functional substances (OFS) offer a versatile approach to modify living materials for enhanced control and monitoring in biological systems. This strategy enables advanced applications in health monitoring and therapeutic interventions.

Area of Science:

  • Biomaterials Science
  • Organic Chemistry
  • Regenerative Medicine

Background:

  • Living materials modification is crucial for controlling biological processes.
  • Organic functional substances (OFS) provide design flexibility and biocompatibility.
  • Current methods offer limited real-time monitoring and precise control.

Purpose of the Study:

  • To review the principles of OFS modification on living materials.
  • To demonstrate applications of engineered living materials.
  • To highlight advancements in health monitoring and therapeutic strategies.

Main Methods:

  • Discussion of OFS properties (small molecules, polymers).
  • Analysis of OFS integration principles with living materials.
  • Review of case studies showcasing engineered living materials.
Keywords:
BiomaterialsBiomedical applicationLiving materialsOrganic functional substance

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Last Updated: Jul 22, 2025

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Main Results:

  • OFS modification allows for real-time sensing, controlled drug release, and enhanced biocompatibility.
  • Engineered living materials demonstrate potential in accurate diagnosis and precise treatment.
  • Applications span health monitoring, drug delivery, wound healing, and tissue regeneration.

Conclusions:

  • OFS modification is an effective strategy for functionalizing living materials.
  • Engineered living materials hold significant promise for diverse biomedical applications.
  • This approach facilitates advancements in personalized medicine and regenerative therapies.