Related Experiment Video

Updated: Jul 22, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

5.1K

Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study

Simon Winther1, Laust Dupont Rasmussen1, Jelmer Westra2

  • 1Department of Cardiology, Gødstrup Hospital, Herning, Denmark.

Open Heart
|July 24, 2023
PubMed

Insights

This study compares two non-invasive imaging methods, Rubidium-82 PET and Oxygen-15 water PET, to accurately diagnose coronary artery disease (CAD) after coronary CTA. It aims to clarify the diagnostic value of selective myocardial perfusion imaging in patients with suspected obstructive CAD.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diagnostic Imaging

Background:

  • Current guidelines suggest functional imaging for myocardial ischemia when coronary CT angiography (CTA) reveals coronary artery disease (CAD) of uncertain significance.
  • The diagnostic accuracy of myocardial perfusion imaging following coronary CTA is not well-established.
  • This research addresses the need for clarity on non-invasive diagnostic tools for obstructive CAD.

Purpose of the Study:

  • To evaluate and compare the diagnostic accuracy of Rubidium-82 PET (Rb-PET) and Oxygen-15 water PET (O-water-PET) for detecting obstructive coronary artery disease (CAD).
  • To assess the utility of selective myocardial perfusion imaging after coronary CTA in symptomatic patients.
  • To provide head-to-head comparison of two PET tracers against invasive coronary angiography.

Main Methods:

  • A prospective, multicentre, cross-sectional study involving approximately 1000 symptomatic patients without prior CAD.
  • Patients underwent coronary CTA, followed by both Rb-PET and O-water-PET if CTA suggested obstructive CAD.
  • Comparison with invasive coronary angiography, including fractional flow reserve and coronary flow reserve measurements, was performed.

Main Results:

  • Data collection and analysis are ongoing.
  • The study is designed to yield definitive comparative diagnostic accuracy data for Rb-PET and O-water-PET.
  • Long-term follow-up will assess cardiovascular events and patient-reported outcomes.

Conclusions:

  • The study will clarify the diagnostic performance of Rb-PET and O-water-PET in identifying functionally significant coronary artery disease.
  • Findings will inform clinical guidelines regarding the use of functional imaging after coronary CTA.
  • This research contributes to optimizing non-invasive diagnostic strategies for patients with suspected obstructive CAD.
Abstract

Keywords:
coronary artery diseasediagnostic imagingpositron-emission tomography

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

457
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

3.6K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
10
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
41
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
9
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
11
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
24
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
42