Related Experiment Video
Updated: Jul 22, 2025
03:37
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
4.6K
Association Between Risperidone Use and Kidney Function Decline in Patients with Schizophrenia: A Retrospective
Megumi Oshima1, Tadashi Toyama1, Yusuke Nakade2
1Department of Nephrology and Laboratory Medicine.
Clinical Therapeutics
|July 24, 2023
Summary
Risperidone use may protect against kidney function decline in schizophrenia patients. This study found a reduced risk of kidney disease progression in those taking risperidone.
Area of Science:
- Nephrology
- Psychiatry
- Pharmacology
Background:
- D-amino acids show protective effects against kidney injury in mice.
- Risperidone, an antipsychotic, inhibits D-amino acid oxidase, an enzyme that degrades D-amino acids.
Purpose of the Study:
- To investigate the association between risperidone use and kidney function decline in patients with schizophrenia.
- To test the hypothesis that risperidone may prevent kidney disease progression.
Main Methods:
- Retrospective cohort study of schizophrenia patients with available serum creatinine data (2010-2020).
- Comparison of patients using risperidone for ≥30 days (risperidone group) versus those with no record of use (control group).
- Cox regression models used to assess the risk of a 40% decline in estimated glomerular filtration rate (eGFR).
Main Results:
- 212 patients in the risperidone group and 1468 in the control group.
- Mean follow-up of 1.6 years; 16% experienced a 40% eGFR decline.
- Adjusted analysis showed risperidone use was associated with a decreased risk of 40% eGFR decline (HR=0.54; P=0.01).
Conclusions:
- Risperidone use may be linked to a reduced risk of kidney function decline in schizophrenia patients.
- Further research is needed to confirm these findings and understand the underlying mechanisms.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
119
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
119
01:11Renal Failure: Dose Adjustments
122
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
122
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
35
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
35
01:28Drug Therapy
71
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
71
01:22Acute Kidney Injury I: Introduction
32
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
32
01:20Antiepileptic Drugs: Potassium Channel Activators
214
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
214