Unlocking full and fast conversion in photocatalytic carbon dioxide reduction for applications in radio-carbonylation

Harvesting sunlight to drive carbon dioxide (CO₂) valorisation represents an ideal concept to support a sustainable and carbon-neutral economy. While the photochemical reduction of CO₂ to carbon monoxide (CO) has emerged as a hot research topic, the full CO₂-to-CO conversion remains an often-overlooked criterion that prevents a productive and direct valorisation of CO into high-value-added chemicals. Herein, we report a photocatalytic process that unlocks full and fast CO₂-to-CO conversion (<10 min) and its straightforward valorisation into human health related field of radiochemistry with carbon isotopes. Guided by reaction-model-based kinetic simulations to rationalize reaction optimisations, this manifold opens new opportunities for the direct access to ¹¹C- and ¹⁴C-labeled pharmaceuticals from their primary isotopic sources [¹¹C]CO₂ and [¹⁴C]CO₂.