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Updated: Jul 22, 2025
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Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
Published on: April 27, 2014
21.8K
Frontal two-electrode transcranial direct current stimulation protocols may not affect performance on a combined
Adrienn Holczer1, Teodóra Vékony2, Péter Klivényi3
1Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Health Centre, University of Szeged, Semmelweis u. 6, Szeged, Hungary. holczer.adrienn@med.u-szeged.hu.
Scientific Reports
|July 24, 2023
Summary
Single-session transcranial direct current stimulation (tDCS) did not alter cognitive control or response inhibition in healthy adults. This study found no significant effects with either anodal or cathodal stimulation targeting the DLPFC or FM regions.
Area of Science:
- Neuroscience
- Cognitive Science
- Neuromodulation
Background:
- Transcranial direct current stimulation (tDCS) is explored for modulating cognitive functions.
- Systematic comparisons of tDCS electrode montages and polarities for cognitive control and response inhibition are lacking.
Purpose of the Study:
- To investigate the effects of anodal and cathodal tDCS on cognitive control and response inhibition.
- To compare different electrode montages (DLPFC vs. FM) in healthy volunteers.
Main Methods:
- Randomized, sham-controlled study with 38 healthy volunteers.
- Single session of sham, anodal, or cathodal tDCS targeting DLPFC or FM regions.
- Participants performed a flanker Go/No-Go task during stimulation.
Main Results:
- No significant effects of tDCS (anodal or cathodal) on cognitive control or response inhibition were observed in either the DLPFC or FM groups.
- No major adverse effects were reported, and sensation profiles did not differ between stimulation types or groups.
Conclusions:
- Single-session tDCS using common parameters and montages may not reliably impact cognitive control or response inhibition.
- Further systematic research is needed to clarify tDCS efficacy, identify response determinants, and optimize its application.
