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Fixing Double-strand Breaks

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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

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Related Experiment Video

Updated: Jul 22, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

A light switch for DNA break repair

Lejon E M Kralemann¹, Marcel Tijsterman^2,3

¹Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.

|July 24, 2023

Summary

No abstract available in PubMed .

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