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Helodermin has a VIP-like effect upon canine blood flow.

S Naruse, A Yasui, S Kishida

    Peptides
    |January 1, 1986
    PubMed
    Summary
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    Helodermin, a peptide from Gila monster venom, acts like vasoactive intestinal peptide (VIP), widening blood vessels. This study shows helodermin

    Area of Science:

    • Pharmacology
    • Vascular Physiology
    • Peptide Research

    Background:

    • Helodermin is a peptide found in Gila monster venom.
    • Vasoactive intestinal peptide (VIP) is a known vasodilator.
    • The cardiovascular effects of helodermin are not fully understood.

    Purpose of the Study:

    • To investigate the vascular and cardiovascular effects of synthetic helodermin in anesthetized dogs.
    • To compare the potency and duration of helodermin's effects with VIP and PHM (human PHI).
    • To identify the active fragments of helodermin responsible for its effects.

    Main Methods:

    • Anesthetized dogs were used as the experimental model.
    • Synthetic helodermin and related peptides were administered via intraarterial infusion and intravenous injection.

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  • Femoral, common carotid, superior mesenteric, and femoral artery blood flow were measured.
  • Systemic blood pressure and heart rate were monitored.

    • Main Results:

    • Intraarterial helodermin increased femoral blood flow in a dose-dependent manner.
    • Helodermin was less potent than VIP but more potent than PHM, with a significantly longer duration of action.
    • Intravenous helodermin caused prolonged hypotension and tachycardia, increased carotid blood flow, and decreased superior mesenteric and femoral blood flow.
    • The N-terminal fragment Hd(1-27)NH2 retained activity but lacked the prolonged effect; other fragments were inactive.

    Conclusions:

    • Helodermin exhibits VIP-like vasodilating activity.
    • Helodermin possesses significant cardiovascular effects, including hypotension and tachycardia.
    • The N-terminal portion of helodermin is crucial for its activity, but the full molecule is required for prolonged effects.