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COVID-19 annual update: a narrative review
Michela Biancolella1, Vito Luigi Colona2, Lucio Luzzatto3,4
1Department of Biology, Tor Vergata University of Rome, 00133, Rome, Italy.
Human Genomics
|July 24, 2023
Summary
Genetic research identifies genes influencing COVID-19 susceptibility and severity, paving the way for new treatments. Continued vigilance and international collaboration are crucial for future pandemic preparedness.
Area of Science:
- Genetics and Genomics
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, continues to be a global health concern despite the WHO declaring the emergency phase over.
- The transition towards an endemic phase necessitates ongoing research into the virus and host-pathogen interactions.
Purpose of the Study:
- To review recent advancements in genetic and genomic research related to COVID-19.
- To explore state-of-the-art therapeutic strategies in light of new genetic findings.
- To emphasize the importance of lessons learned from COVID-19 for future pandemic preparedness.
Main Methods:
- Analysis of genetic and genomic data, including sequencing and characterization of rare alleles.
- Review of current literature on COVID-19 genetics and therapeutic approaches.
Main Results:
- Identification of numerous genes impacting susceptibility and severity of COVID-19 through the study of rare alleles across diverse populations.
- Establishment of a foundation for novel pan-ethnic therapeutic strategies and genetic screening protocols.
Conclusions:
- Genetic insights offer promising avenues for targeted therapies and personalized medicine for COVID-19.
- The findings underscore the need for sustained research, global cooperation, and data sharing to combat current and future viral threats.
- Lessons learned regarding origins, response, and preparedness are critical for preventing future global health crises.
Keywords:
COVID-19CoronavirusPandemicPublic healthSARS-CoV-2Susceptibility genesTherapyVaccinesVariantsMore Related Videos
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