Related Experiment Video

Updated: Jul 18, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

9.7K

Efficacy of probiotics in pediatric atopic dermatitis: A systematic review and meta-analysis

Xiali Xue1, Xinwei Yang1, Xiubo Shi2

  • 1School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.

Clinical and Translational Allergy
|July 25, 2023
PubMed

Insights

Probiotics show a positive effect on atopic dermatitis (AD) in children, particularly single-strain treatments. However, more high-quality studies are needed to confirm these findings for pediatric AD management.

Area of Science:

  • Pediatric Dermatology
  • Microbiome Research
  • Clinical Trials

Background:

  • Atopic dermatitis (AD) is a common childhood skin condition.
  • Probiotics are being investigated as a potential treatment for AD.
  • This study evaluates the efficacy of probiotics in pediatric AD.

Purpose of the Study:

  • To assess the effectiveness of probiotic interventions in improving the SCORAD (Severity of Atopic Dermatitis) value in children with AD.
  • To systematically review randomized controlled trials (RCTs) comparing probiotic treatment to placebo for pediatric AD.

Main Methods:

  • Systematic literature search of multiple databases (PubMed, Embase, Scopus, etc.) for RCTs published between January 2010 and January 2023.
  • Included studies focused on pediatric patients with AD, assessing SCORAD values.
  • Risk of bias and certainty of evidence were evaluated using Cochrane ROB 2.0.

Main Results:

  • Analysis of 9 RCTs with 1000 patients revealed no significant difference in dichotomous outcomes between probiotic and control groups (p=0.23).
  • Meta-analysis of continuous variables showed a significant improvement in SCORAD values with probiotic treatment (p=0.002).
  • Subgroup analyses indicated no statistically significant effect of age, treatment duration, or probiotic species on SCORAD values.

Conclusions:

  • Current evidence suggests limited but positive effects of probiotics on pediatric AD, especially single-strain formulations.
  • High-quality studies are required to validate these findings due to limitations in the quantity and quality of included research.
Abstract

Keywords:
atopic dermatitischildrenmeta-analysisprobioticstreatment

More Related Videos

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.2K
Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

851

Related Concept Videos

Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...