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Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
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Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

356

A Cadaveric Evaluation of Hypertrophic Obstructive Cardiomyopathy

Celeste M Murtha1, John R Dobson2, Anthony B Olinger3

  • 1Anatomy, College of Osteopathic Medicine, Kansas City University, Kansas City, USA.

Cureus
|July 25, 2023
PubMed

Insights

This case report details hypertrophic obstructive cardiomyopathy (HOCM) in an embalmed cadaver. Histologic analysis confirmed HOCM, demonstrating the diagnostic value of embalmed cardiac tissue.

Area of Science:

  • Cardiovascular Pathology
  • Medical Education Anatomy

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by interventricular septum hypertrophy and fibrosis, leading to left ventricular outflow obstruction.
  • Understanding HOCM's gross and microscopic features is crucial for diagnosis and management.

Observation:

  • A 36-year-old male cadaver, embalmed for 11 months, was evaluated for HOCM.
  • The heart weighed 510.1g, significantly exceeding the predicted average.
  • While septal and free wall thickness were noted, asymmetrical left ventricular thickening was less pronounced than typical.

Findings:

  • Histologic examination using H&E, trichrome, and desmin staining confirmed HOCM in the cadaveric cardiac tissue.
  • Embalmed tissue, even after 11 months, proved effective for diagnostic histologic evaluation.
  • Morphologic and histologic analyses of cadaveric tissue are sufficient for diagnosing HOCM.

Implications:

  • This study validates the use of embalmed cadaveric tissue for diagnosing cardiovascular conditions like HOCM.
  • It highlights the utility of donated cadavers in medical education and research for understanding complex pathologies.
  • The findings support the continued use of cadaveric dissection and histology in anatomical and pathological studies.

Keywords:
asymmetric septal hypertrophycardiac sudden deathfamilial hypertrophic cardiomyopathyhypertrophic obstructive cardiomyopathy (hocm)idiopathic hypertrophic subaortic stenosis

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