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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

219
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
219
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

175
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
175
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

171
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
171
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

560
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
560
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

486
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
486

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Updated: Jul 22, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Pediatric Ulcerative Colitis in Siblings.

Divya Mamootil1

  • 1Internal Medicine, Ascension St. Agnes Hospital, Baltimore, USA.

Cureus
|July 25, 2023
PubMed
Summary

A pediatric case report details a nine-year-old girl diagnosed with ulcerative colitis (UC), a form of inflammatory bowel disease (IBD). Genetic factors and diagnostic findings are discussed for this young patient.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease (IBD) Research
  • Clinical Case Studies

Background:

  • Inflammatory bowel disease (IBD) diagnosis in children presents unique challenges.
  • Genetic predisposition is a significant factor in pediatric IBD, exemplified by a family history of ulcerative colitis (UC).

Observation:

  • A nine-year-old female presented with symptoms including abdominal pain, diarrhea, and weight loss.
  • Imaging revealed bowel thickening, and stool studies showed elevated inflammatory markers and occult blood.

Findings:

  • Colonoscopy and rectal biopsy confirmed the diagnosis of ulcerative colitis (UC).
  • Elevated lactoferrin, calprotectin, and occult blood in stool supported the diagnosis.

Implications:

Keywords:
biologic therapiesimmunosuppression therapyirritable bowel diseasepediatric geneticssteroid treatmentulcerative colitis (uc)

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  • This case highlights the importance of considering genetic factors in pediatric IBD.
  • Early diagnosis and appropriate management are crucial for improving outcomes in pediatric ulcerative colitis.