Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.8K
Overview
27.8K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

447
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
447
Hypersensitivities01:30

Hypersensitivities

747
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
747
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

879
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
879

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent Driving Intentions and Licensure by Neighborhood Opportunity.

JAMA pediatrics·2026
Same author

A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

Pediatrics·2026
Same author

Malfunctions in distributed clinical decision support: 3 cases from a multi‑component clinical decision support system.

Journal of the American Medical Informatics Association : JAMIA·2026
Same author

Precision medicine in eosinophilic esophagitis.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Association of Stress and Neighborhood Social Context With Actigraphy-Measured and Self-Reported Adolescent Sleep Outcomes.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2026
Same author

Innovation to Improve Detection of Early Developmental and Behavioral Concerns.

JAMA network open·2026

Related Experiment Video

Updated: Jul 22, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K

Patterns in the Development of Pediatric Allergy.

Stanislaw J Gabryszewski1, Jesse Dudley2, Di Shu2,3

  • 1Division of Allergy and Immunology.

Pediatrics
|July 25, 2023
PubMed
Summary

Pediatric allergy patterns reveal high incidence of atopic dermatitis (AD) and asthma. Many children experience multiple allergic conditions, supporting the concept of an allergic march from food to respiratory allergies.

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.4K
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.1K

Related Experiment Videos

Last Updated: Jul 22, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.4K
Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

15.1K

Area of Science:

  • Pediatric Allergy and Immunology
  • Epidemiology
  • Electronic Health Records Research

Background:

  • Pediatric allergies represent a significant public health concern with complex clinical and epidemiologic patterns.
  • Understanding the progression and co-occurrence of allergic diseases in children is crucial for effective management and prevention strategies.

Purpose of the Study:

  • To describe the clinical and epidemiologic patterns of pediatric allergies.
  • To analyze the incidence, age at diagnosis, and comorbidities of various allergic conditions in children using longitudinal data.

Main Methods:

  • Utilized a multistate EHR database (Comparative Effectiveness Research through Collaborative Electronic Reporting) from 1999-2020.
  • Defined a cohort of 218,485 children (0-18 years) with a minimum 5-year observation period.
  • Identified atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) using diagnosis codes and medication data.

Main Results:

  • Cumulative incidence rates were highest for asthma (20.1%) and allergic rhinitis (19.7%), with early peak ages of diagnosis (13 months for asthma, 26 months for AR).
  • Atopic dermatitis showed a high cumulative incidence (10.3%) with a very early peak diagnosis at 4 months.
  • Food allergies, particularly peanut (1.9%) and egg (0.8%), were diagnosed later. A significant proportion (13.4%) had multiple allergic conditions, with common comorbidities between respiratory allergies and other allergic diseases.

Conclusions:

  • Longitudinal EHR data from diverse US pediatric practices provide detailed insights into pediatric allergy epidemiology.
  • Findings support the 'allergic march' phenomenon, where children progress from conditions like atopic dermatitis to food and respiratory allergies.
  • High rates of comorbidity among food and respiratory allergies underscore the need for integrated management approaches in pediatric allergy care.