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Updated: Jul 22, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Oncogenic Proteomics Approaches for Translational Research and HIV-Associated Malignancy Mechanisms

Eduardo Alvarez-Rivera1, Emanuel J Ortiz-Hernández1, Elyette Lugo1

  • 1Biomedical Proteomics Facility, Department of Microbiology and Immunology, Universidad Central del Caribe, School of Medicine, Bayamón, PR 00960, USA.

Proteomes
|July 25, 2023
PubMed

Insights

Proteomics advances enable discovery of cancer biomarkers for disease prediction and precision medicine. Mass spectrometry aids validation, with potential applications in understanding virus-associated malignancies like those in HIV-1 patients.

Area of Science:

  • Proteomics and molecular biology
  • Cancer research and precision medicine
  • Virology and oncogenesis

Background:

  • Proteomics offers deep insights into cellular molecular regulation and signaling pathways.
  • Data mining in proteomics aids in identifying disease mechanisms and prognostic markers for cancer.
  • Mass spectrometry (MS) is crucial for validating protein biomarkers.

Purpose of the Study:

  • To review current developments in MS-based quantitative proteomics for clinical applications.
  • To explore the integration of proteomics data in cancer precision medicine.
  • To discuss oncogenic virus-associated malignancies, including those in Acquired Immunodeficiency Syndrome (AIDS) and Human Immunodeficiency Virus type-1 (HIV-1) patients.

Main Methods:

  • Review of recent advancements in MS sensitivity and quantitative proteomics.
  • Analysis of data mining approaches for biomarker discovery.
  • Discussion of oncogenic mechanisms of Human Immunodeficiency Virus type-1 (HIV-1) proteins.

Main Results:

  • Proteomics, particularly MS, is advancing biomarker discovery and validation for cancer.
  • Quantitative proteomics is moving towards clinical settings for precision medicine applications.
  • HIV-1 proteins contribute to oncogenesis through various cellular stresses and interactions.

Conclusions:

  • Proteomics holds significant promise for advancing cancer precision medicine through biomarker discovery and validation.
  • Understanding the role of viral proteins in oncogenesis is critical for managing virus-associated cancers.
  • Integrating quantitative proteomics into clinical practice will enhance cancer diagnosis, prognosis, and treatment.
Keywords:
HIV-associated malignanciesbiomarkerscancerco-morbiditymass spectrometryquantitative proteomics

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