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Pulmonary Pathogen-Induced Epigenetic Modifications
Dylan Wrede1, Mika Bordak1, Yeabtsega Abraham1
1School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Epigenomes
|July 25, 2023
Summary
Respiratory pathogens can alter host cell epigenetics, influencing chronic lung diseases. This review explores how DNA methylation and histone modifications by microbes contribute to lung disease development.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Epigenetics involves gene expression regulation beyond DNA sequence.
- Key epigenetic mechanisms include DNA methylation and histone modification.
- Epigenetic changes influence cellular processes and disease-associated gene expression.
Purpose of the Study:
- To review the impact of respiratory pathogens on host cell epigenetic modifications.
- To explore the link between pathogen-induced epigenetic changes and chronic lung disease pathophysiology.
Main Methods:
- Literature review focusing on epigenetic modulations induced by respiratory pathogens.
- Analysis of studies investigating DNA methylation and histone modification in response to viral, bacterial, and fungal infections.
Main Results:
- Respiratory pathogens (viruses, bacteria, fungi) induce epigenetic changes in host cells.
- These pathogen-induced epigenetic modulations can affect host defense mechanisms.
- Epigenetic alterations may facilitate pathogen persistence within the host.
Conclusions:
- A direct link between respiratory infections, host epigenetics, and chronic lung diseases is emerging.
- Pathogen-induced epigenetic modifications are potential contributors to lung disease development.
- Understanding these epigenetic mechanisms could offer new therapeutic targets for lung diseases.
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