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Published on: December 19, 2020
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Cognitive Aspects of COVID-19
Ezekiel Gonzalez-Fernandez1, Juebin Huang2
1Department of Neurology, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS, 39216, USA.
Current Neurology and Neuroscience Reports
|July 25, 2023
Summary
Long COVID can cause lasting cognitive impairment, affecting attention, memory, and executive functions. Research is ongoing to understand these neurological effects and potential links to dementia and Alzheimer's disease.
Area of Science:
- Neurology
- Infectious Diseases
- Cognitive Science
Background:
- The coronavirus disease 2019 (COVID-19) pandemic has led to the recognition of persistent neurological complications, termed long COVID syndrome.
- Cognitive impairment is a significant and recognized neurological sequela of COVID-19 infection.
Purpose of the Study:
- To provide a narrative review summarizing the cognitive aspects of COVID-19.
- To highlight the key cognitive domains affected and potential underlying mechanisms.
Main Methods:
- This review synthesizes findings from existing literature on cognitive dysfunction following COVID-19.
- It examines studies reporting on neuroimaging, biofluid analyses, and neurophysiological data related to post-COVID cognitive impairment.
Main Results:
- Attention, memory, and executive functions are consistently identified as the most frequently impaired cognitive domains post-COVID-19.
- Neuroimaging, biofluid, and neurophysiological abnormalities are reported, suggesting pathophysiological underpinnings.
- Evidence indicates a potential bidirectional relationship between COVID-19 and neurodegenerative diseases like Alzheimer's disease, with increased risks observed in both directions.
Conclusions:
- Post-COVID cognitive dysfunction is a widespread and complex issue, with current understanding being in its early stages.
- Further research involving a multidisciplinary approach is crucial for elucidating long-term effects, mechanisms, and therapeutic strategies.
- Understanding the intricate relationship between COVID-19 and cognitive health is essential for patient care and public health strategies.
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