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Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism
Magdy Mohamed Allam1, Hanaa Tarek El-Zawawy2, Tarek Hussein El-Zawawy3
1Internal Medicine Department, Endocrinology division, Alexandria University Student Hospital, Alexandria, Egypt. M_MOHAMED0902@ALEXMED.EDU.EG.
Endocrine
|July 25, 2023
Summary
Subclinical hyperthyroidism (SCH) is linked to reduced renal vascular resistance. Changes in thyroid hormones and blood pressure may explain these renal function alterations in SCH patients.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Medicine
Background:
- Subclinical hyperthyroidism (SCH) is associated with renal dysfunction, but its specific effects on kidney vasculature remain unclear.
- While overt hyperthyroidism causes hypertension, the impact of SCH on renal function and vasculature requires further investigation.
Purpose of the Study:
- To evaluate renal function and vascular changes in patients with SCH.
- To determine the relationship between these renal alterations and hypertension in SCH patients.
Main Methods:
- Included 321 SCH patients and 80 controls, assessing thyroid function, renal markers (creatinine, eGFR), and vascular parameters (TPR, FMD, RAD).
- Utilized laboratory tests and imaging techniques including ultrasound and echocardiography.
Main Results:
- SCH patients exhibited lower serum creatinine and higher eGFR compared to controls.
- Significant reductions in total peripheral resistance (TPR) and flow-mediated dilatation (FMD) were observed in the SCH group.
- Renal Arterial distensibility (RAD) was notably higher in hypertensive SCH patients.
Conclusions:
- Subclinical hyperthyroidism is associated with reduced vascular resistance.
- Thyroid hormone levels and blood pressure dynamics are potential drivers of renal function changes in SCH.
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