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Do Polymorphisms Predict Hypnotherapy Response in Children With Functional Abdominal Pain Disorders: An Explorative

Clara M A de Bruijn1, Stefan W Hovy2, Ellen Tromp3

  • 1From the Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, The Netherlands.

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|July 25, 2023
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Summary
This summary is machine-generated.

Genetic variations in COMT, OPRM1, and MAO-A do not predict hypnotherapy response in children with functional abdominal pain disorders. This study found no association between these genetic polymorphisms and treatment success in pediatric patients.

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Area of Science:

  • Genetics
  • Pediatrics
  • Psychology

Background:

  • Specific gene polymorphisms (COMT, OPRM1, MAO-A) are linked to hypnotizability in adults.
  • Hypnotherapy (HT) shows efficacy for functional abdominal pain disorders (FAPD) in children.
  • The genetic basis for HT response in pediatric FAPD remains unexplored.

Purpose of the Study:

  • To investigate the association between COMT, OPRM1, and MAO-A gene polymorphisms and hypnotherapy treatment success in children with FAPD.
  • To explore potential links between these polymorphisms and secondary outcomes like pain relief, anxiety, and quality of life.

Main Methods:

  • Exploratory study involving 144 pediatric patients (8-18 years) with FAPD from a prior HT trial.
  • Buccal samples collected for genotyping of COMT, OPRM1, and MAO-A polymorphisms.
  • Analysis of associations between genotypes and treatment success after 3-month HT, along with secondary outcome measures.

Main Results:

  • No significant associations were found between variations in COMT, MAO-A, and OPRM1 polymorphisms and treatment success (TS) in pediatric FAPD patients.
  • These genetic polymorphisms did not predict adequate relief, anxiety, depression, quality of life, somatization, hypnotic susceptibility, expectations, pain beliefs, or coping strategies.

Conclusions:

  • COMT, OPRM1, and MAO-A gene polymorphisms do not appear to be predictors of hypnotherapy response in pediatric patients diagnosed with functional abdominal pain disorders.
  • Further research may be needed to identify genetic or other factors influencing hypnotherapy outcomes in this population.