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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
Xianwang Wang1, Yihua Shen2, Xingxia Wan3
1Department of Biochemistry and Molecular Biology, Health Science Center, Yangtze University, Jingzhou, 434023, Hubei, China. 275379987@qq.com.
Journal of Translational Medicine
|July 25, 2023
Summary
Oncolytic virotherapy (OVT) uses engineered oncolytic viruses (OVs) to target cancer. Emerging fourth-generation OVT strategies, like those using bi-specific T cell activators, show promise for enhanced immunotherapy and combination treatments.
Area of Science:
- Oncology
- Immunotherapy
- Virology
Background:
- Oncolytic virotherapy (OVT) employs oncolytic viruses (OVs) for targeted cancer treatment.
- Examples like Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401) highlight OV advancements.
- Optimizing safety, efficacy, and combination strategies remains crucial for clinical success.
Purpose of the Study:
- To critically review the development and current status of OVT.
- To explore mechanisms for enhancing OV safety and efficacy.
- To discuss novel strategies and clinical trial progress in OVT.
Main Methods:
- Systematic review of preclinical and clinical OVT studies.
- Analysis of OVT mechanisms, focusing on safety and efficacy enhancement.
- Evaluation of emerging strategies, including bi-specific T cell activators (BiTA).
Main Results:
- Oncolytic virotherapy has evolved into a fourth-generation tumor immunotherapy.
- Designing OVs to express bi-specific T cell activators (BiTA) is a promising strategy.
- Combinations of OVs with immune cells offer significant potential for cancer management.
Conclusions:
- Oncolytic viruses (OVs) are advancing into clinical trials.
- OVs are poised to become frontier clinical anti-tumor agents.
- Further research into OVT combination therapies is warranted.
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