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Pharmacological changes induced by repeated exposure to phenylethylamine.

G Gianutsos, S Chute

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1986
    PubMed
    Summary

    Daily phenylethylamine (PEA) injections in mice led to heightened motor stimulation and increased sensitivity to stimulants like amphetamine. This sensitization is linked to elevated dopamine receptor activity, not altered metabolism.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Neurobiology

    Background:

    • Phenylethylamine (PEA) is an endogenous trace amine with stimulant properties.
    • Understanding the long-term effects of PEA administration is crucial for its neurobiological implications.
    • Investigating potential mechanisms of drug sensitization is important in pharmacology.

    Purpose of the Study:

    • To investigate the effects of chronic phenylethylamine (PEA) administration on motor stimulation in mice.
    • To determine if PEA treatment alters sensitivity to other psychostimulant drugs.
    • To explore the underlying neurobiological mechanisms of PEA-induced sensitization.

    Main Methods:

    • Mice received daily injections of phenylethylamine (PEA) over an extended period.
    • Motor activity was assessed to measure PEA-induced stimulation.

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  • Sensitivity to amphetamine and phencyclidine (PCP) was evaluated.
  • Monoamine oxidase (MAO) and hepatic mixed function oxidase activities were measured.
  • Dopamine receptor density was assessed using spiroperidol binding assays.

    • Main Results:

    • Chronic PEA administration resulted in enhanced PEA-induced motor stimulation starting from day 21.
    • Mice treated with PEA showed increased sensitivity to the stimulant effects of amphetamine and PCP.
    • No significant changes were observed in brain or hepatic monoamine oxidase activity.
    • Hepatic mixed function oxidase activity remained unchanged.
    • Long-term PEA treatment led to an increase in striatal dopamine receptors.

    Conclusions:

    • Chronic phenylethylamine (PEA) administration induces behavioral sensitization in mice.
    • This sensitization may be attributed to an upregulation of dopaminergic receptor activity.
    • Altered drug metabolism is not the primary mechanism behind PEA-induced sensitization.